Concomitant consumption of alcoholic beverages along with sustained release products might be expected to have the potential to induce dose dumping. No concrete research has been taken to evaluate the role of various beverages and drinks on the drugs ââ?¬â?? specifically sustained release dosage forms. The literature review definitely points to the lacunas in the field of this area of research. Hence, the objective of present study is to correlate in vitro drug release pattern of sustained released dosage forms in presence of alcoholic beverages with ex vivo drug absorption pattern. Reliable and predictive in vitro methods to quantify drug transport across the intestinal epithelium are required at an early stage in the drug development process for oral solid dosage forms. Several approaches have been used to obtain the most representative model of the intestinal epithelium. The everted intestine model presents many advantages relative to other methods. In this work, an attempt has been made to develop an ex vivo continuous dissolutionââ?¬â??absorption system to study the effect of alcohol consumption on sustained release formulation of metformin and diclofenac. The studies yielded a dissolutionââ?¬â??absorption relationship that can be used to predict dissolution or permeation-rate-limited absorption for two marketed formulations. Thus, the dissolutionââ?¬â??absorption system may prove to be a valuable tool in formulation development. Broader evaluation of such a system is warranted.
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